Show Summary Details

Page of

PRINTED FROM OXFORD HANDBOOKS ONLINE (www.oxfordhandbooks.com). © Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Handbooks Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 November 2019

Abstract and Keywords

That genes influence how we feel and behave is without question. Yet despite decades of research, the mechanisms through which this occurs are only recently coming into focus. This chapter reviews studies that have contributed toward narrowing the gap in knowledge regarding genes and emotional behavior. First, the discussion focuses on Williams syndrome, a genetic “lesional” model, which offers an exceptional framework for understanding the relationship between genes, brain circuits, and atypical socioemotional behavior. The chapter then reviews recent findings for the more common case of mood disorders, for which as for most psychiatry conditions the genetics are complex. The concepts of intermediate phenotypes and imaging genetics will be introduced here as tools to address this question. Finally, evidence at the neurochemical level is presented which suggests that prosocial neuropeptides play a crucial role in the neurobiological chain linking genes and emotion.

Keywords: Williams syndrome, microdeletion syndrome, amygdala, fusiform face area, serotonin, 5-HTTLPR, brain-derived neurotrophic factor (BDNF), monoamine oxidase a (MAO-A)

Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.