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date: 07 July 2020

Abstract and Keywords

This chapter examines the neural underpinnings of episodic memory, focusing on processes taking place during the experience itself, or encoding, and those involved in memory reactivation or retrieval at a later time point. It first looks at the neuropsychological case study of Henry Molaison to show how the medial temporal lobe (MTL) is linked to the formation of new episodic memories. It also assesses the critical role of the MTL in general and the hippocampus in particular in the encoding and retrieval of episodic memories. The chapter then describes the memory as reinstatement model, episodic memory retrieval, the use of functional neuroimaging as a tool to probe episodic memory, and the difference in memory paradigm. Furthermore, it discusses hippocampal activity during encoding and its connection to associative memory, activation of the hippocampus and cortex during episodic memory retrieval, and how hippocampal reactivation mediates cortical reactivation during memory retrieval.

Keywords: episodic memory, medial temporal lobe, Henry Molaison, memory retrieval, encoding, memory reactivation, hippocampus, memory as reinstatement model, functional neuroimaging, associative memory

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