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date: 18 September 2019

Abstract and Keywords

This chapter examines premenstrual dysphoric disorder (PMDD) and the less restricted condition of clinically significant premenstrual syndrome (PMS). PMDD is distinguished from a clinical diagnosis of PMS by the number of specific symptoms required for a PMDD diagnosis. Both are characterized by changes in mood as well as behavioral and physical symptoms that occur in relation to regular menstrual cycles and impair functioning. Circulating levels of the reproductive hormones are in the normal range, but some women may be vulnerable to the normal fluctuations of one or more of these hormones. The chapter presents the epidemiology, diagnosis, and treatments of PMDD/PMS based on evidence in randomized clinical trials. There is no one treatment that entirely fits this complex disorder, but the weight of current evidence supports treatments aimed at modifying serotonin transmission or suppressing ovulation. The chapter concludes with suggestions for further research to increase our knowledge of the causes and treatments of menstrually related disorders.

Keywords: premenstrual dysphoric disorder, premenstrual syndrome, diagnosis, antidepressants, oral contraceptives

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