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date: 26 January 2021

Abstract and Keywords

Evidence from case-control family studies demonstrates that hoarding is more common among first-degree relatives of people with hoarding compared with nonhoarding controls. Multiplex pedigree and twin studies suggest that hoarding has a strong genetic component and complex pattern of inheritance; evidence indicates that genetic factors account for approximately half of the phenotypic variance in hoarding. Gene-finding studies, while not yet conclusive, have tentatively implicated regions on chromosomes 4, 5, 6, 14, 17, and 19. Gene-testing studies have examined the hoarding phenotype and a few genes previously implicated in obsessive–compulsive disorder (OCD) including COMT, NTRK3, and SLC1A1. However, none of these genes has yet been clearly implicated as susceptibility genes for hoarding. Two major limitations of the available literature are (a) the common use of subjects diagnosed with OCD or Tourette syndrome, rather than samples examining hoarding as a primary rather than secondary phenotype, and (b) the lack of replication of the few existing genetic studies.

Keywords: Hoarding disorder, obsessive–compulsive disorder, Tourette syndrome, genetics, heritability, twin studies, linkage analysis, genomewide association study, candidate gene study

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