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date: 02 June 2020

Abstract and Keywords

The case of Phineas Gage is one of the most frequently cited cases from 19th century medical literature and represents the first of a series of famous cases involving the brain and behavior. While many reiterations of Gage’s case have been published, it remains important to modern neuroscience due to its unique historical significance, ongoing clinical relevance, and the insights it offers neuropsychology into the functional effects of brain injury on thinking, emotions, and behavior. This chapter revisits the critical aspects of this landmark case from a contemporary clinical perspective and discusses the implications of injury to the prefrontal cortex and pathways.

Keywords: Phineas Gage, traumatic brain injury, prefrontal cortex, neuropsychology, frontal lobe injuries, prefrontal cortex, organic mood disorder, historical case studies, 19th century medicine

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