Given the increasing prevalence of job insecurity across the globe, the purpose of this chapter is to identify variables operating at the individual, occupational, organizational, and societal levels that have been found to influence employee perceptions of job insecurity and to discuss the outcomes (related to organizational well-being and employee well-being) that accrue as a result of such insecurity. In doing so, we bring together two disparate bodies of literature on economic stress (job insecurity and anticipated job loss) by integrating them into a comprehensive model that explicitly advocates a multilevel perspective and acknowledges that employees are embedded in multiple intersecting and influential contexts (e.g., socioeconomic conditions). Although a vast body of research suggests that the consequences of job insecurity are largely negative, this chapter also explores organizational- and societal-level interventions to attenuate these negative consequences.