Show Summary Details

Page of

PRINTED FROM OXFORD HANDBOOKS ONLINE ( © Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Handbooks Online for personal use (for details see Privacy Policy and Legal Notice).

date: 10 April 2021

Abstract and Keywords

We review behavioral and biometrical genetic research aimed at characterizing the nature of the familial aggregation of adolescent substance use and abuse. Twin and adoption studies have shown that genetic factors contribute to individual differences in adolescent substance use phenotypes. These studies have also documented the importance of the shared environment. Biometrical analyses of large samples of twins show that the contributions of genetic and shared environmental factors to substance use phenotypes change markedly between adolescence and early adulthood. The importance of genetic influence increases with age as the importance of shared environmental influences declines. Although only a small number of relevant genetic variants have been identified at this time, they show a similar pattern of increasing association with substance use behavior with age. A major question continues to be how genetic and environmental factors operate jointly to influence the development of complex behavioral phenotypes such as substance use.

Keywords: twin studies, adoption studies, heritability, biometrical genetics, candidate-gene associations, genome-wide association studies, gene–environment correlation, gene–environment interaction

Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.