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date: 26 January 2020

Abstract and Keywords

Recent advances in neurobiology have increased our understanding of the role of neurotransmitters, genetics, and brain networks in the regulation of normal behavior, individual differences in personality, and psychopathology of personality disorders. Individual differences in the regulation and organization of cognitive processes, including the experience of psychotic-like perceptual distortions and deficit symptoms, are typical in Cluster A personality disorders or schizophrenia spectrum personality disorders, such as schizotypal. Personality dimensions such as affective instability, emotional information processing, aggression, and impulsivity are typical for borderline personality disorder and other Cluster B personality disorders. A low threshold for anxiety and presence of compulsivity may contribute to the avoidant, dependent, and compulsive behaviors observed in Cluster C personality disorders. It is widely accepted that an endophenotypic approach will provide a better understanding of pathophysiological mechanisms and clarify the underlying candidate genes contributing to these behavioral dimensions, as well as susceptibility to major psychiatric illnesses.

Keywords: avoidant, borderline, schizotypal, candidate gene, cognitive, endophenotype, genetic, neurochemistry, neuroimaging, pharmacotherapy, psychophysiology

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