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date: 24 January 2021

Abstract and Keywords

Depression is among the most prevalent emotional disorders in neuropsychiatry. Given the comorbidity between symptoms of depression and symptoms of many neurological disorders, neuropsychiatric approaches to diagnosis and management are complex. This chapter will examine the epidemiology, clinical correlates, and treatment of depression in the three most common neurological disorders in old age, namely stroke, Alzheimer’s disease and Parkinson’s disease. Depression in neurological disorders should be diagnosed with structured diagnostic interviews and standardized diagnostic criteria. Depression is highly prevalent in neurological disorders and has a negative impact on activities of daily living and cognition. Response to pharmacological treatment of depression is variable among patients with such neurological disorders. Stroke patients and patients with Parkinson’s disease show significant benefits from psychotropic medication, but it does not seem to benefit patients with Alzheimer’s disease. Psychological interventions may be beneficial, but further studies are needed.

Keywords: depression, stroke, Alzheimer's disease, Parkinson's disease, anxiety ageing

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