The issue of Islam and modern science, along with its progeny, modern technology, continues today as one of the most crucial faced by the Islamic community. It has been, and continues to be, addressed by numerous scholars and thinkers, covering nearly the whole gamut of the spectrum of Islamic intellectual activity since the last century. This article analyses modern science and subjects it to an in-depth criticism from the Islamic point of view, drawing from the Islamic intellectual tradition. It holds that any science that could legitimately be called Islamic science, and not be disruptive of the whole Islamic order, must be one that remains aware of the ‘vertical cause’ of all things, along with the horizontal, a science that issues from and returns to the Real (al-Haqq), who is the cause of all things.