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date: 05 July 2020

Abstract and Keywords

Based on the framework of gene–environment interactions (G  E), the gene–culture interaction framework demonstrates that a more complete understanding of thoughts and behaviors relevant to health may come from incorporating both genetic and cultural factors. Genes may interact with culture such that genetic predispositions lead to different outcomes depending on culture, and cultural differences on a given outcome may vary depending on genetic predispositions. We provide an overview of G  E research and some of the underlying biological mechanisms of these interactions. We explain the gene–culture interaction framework and discuss how culture is an important form of environment to consider that makes theoretical contributions unique from other forms of environment typically studied in G  E research. We discuss theoretical questions raised by gene–culture interaction research and specify how the gene–culture interaction framework can be applied to certain health issues.

Keywords: Gene–environment interaction, gene–culture interaction, determinants of health, framework, culture

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