Show Summary Details

Page of

PRINTED FROM OXFORD HANDBOOKS ONLINE ( © Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Handbooks Online for personal use (for details see Privacy Policy and Legal Notice).

date: 14 August 2020

Abstract and Keywords

Quantitative behavioral genetics studies provide strong evidence for heritable influences on the development of externalizing spectrum behaviors that cut across traditional diagnostic boundaries, including attention-deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, antisocial personality disorder, and substance use and dependence. In contrast, molecular genetic studies have focused largely on individual disorders. This chapter reviews findings from genome-wide linkage studies, candidate gene studies, and genome-wide association studies of externalizing spectrum disorders, highlighting genes and gene categories that show relations with multiple disorders on the spectrum. Although still somewhat limited, these results provide important insights into the genetic architecture of the externalizing spectrum. The authors also note substantial divergence in findings across study designs, provide potential explanations for such findings, and describe how future studies might resolve these discrepancies.

Keywords: externalizing spectrum disorders, behavior, molecular genetics, genes, genetics studies

Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.