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date: 14 August 2020

Abstract and Keywords

This chapter discusses substance use disorders (SUDs) as externalizing outcomes while also touching on psychopathy. It begins by reviewing available evidence regarding general dispositional vulnerability to SUDs and conditions involving impulsivity and antisocial behavior. It then considers brain systems implicated in inhibitory control and reward-seeking behavior, along with their relationship to substance use problems. It also describes an empirically based organizing framework, the externalizing spectrum model, for identifying similarities and differences among externalizing outcomes in terms of symptomatic features and causal origins. It explores the psychological and neurobiological mechanisms underlying general vulnerability to externalizing problems, as well as the factors that influence this vulnerability in the direction of SUDs compared to other outcomes. The chapter concludes with an assessment of some relevant unresolved questions and directions for future research.

Keywords: substance use disorders, externalizing outcomes, psychopathy, impulsivity, antisocial behavior, brain systems, inhibitory control, reward-seeking behavior, externalizing spectrum model

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