Show Summary Details

Page of

PRINTED FROM OXFORD HANDBOOKS ONLINE ( © Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Handbooks Online for personal use (for details see Privacy Policy and Legal Notice).

date: 21 May 2019

Abstract and Keywords

Effective reception, delivery, and processing of information is fundamental to all life forms. Physical and chemical signals are perceived from both outside and inside an organism. The nature, duration, and intensity of signals are processed into information, mainly encoded as concentration differences of ions and molecules that ultimately lead to a reaction of the organism. Although the advent of the first and most primitive signalling system will remain unknown, it probably existed already in the first hours of life. Disturbances of well-orchestrated signalling systems are often the basis of diseases. Understanding the complexity of signalling networks is required for rational intervention in different disease stages. Understanding the evolutionary history of signalling systems can help us unveil the requirements for proper functioning of a given signalling network. This chapter provides an overview of how cellular communication evolved, works, and contributes to our understanding of human diseases in the light of evolution.

Keywords: information, signalling, disease, signalling network, evolutionary history, cellular communication, evolutionary medicine

Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.