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date: 18 June 2019

Abstract and Keywords

This article discusses a series of recent applications of random matrix theory (RMT) to the problem of RNA folding. It first provides a schematic overview of the RNA folding problem, focusing on the concept of RNA pseudoknots, before considering a simplified framework for describing the folding of an RNA molecule; this framework is given by the statistic mechanical model of a polymer chain of L nucleotides in three dimensions with interacting monomers. The article proceeds by presenting a physical interpretation of the RNA matrix model and analysing the large-N expansion of the matrix integral, along with the pseudoknotted homopolymer chain. It extends previous results about the asymptotic distribution of pseudoknots of a phantom homopolymer chain in the limit of large chain length.

Keywords: random matrix theory (RMT), RNA folding, RNA pseudoknot, RNA molecule, polymer chain, matrix model, matrix integral, homopolymer chain, asymptotic distribution

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