- Series Information
- The Oxford Handbook of Transcranial Stimulation
- List of Contributors
- Section I Physics and Biophysics of TMS
- TMS waveform and current direction
- TMS stimulator design
- TMS stimulation coils
- Magnetic field stimulation: the brain as a conductor
- Lessons learned from magnetic stimulation of physical models and peripheral nerve <i>in vitro</i>
- Direct current brain polarization
- Transcranial electrical stimulation and intraoperative neurophysiology of the corticospinal tract
- Section II TMS Measures of Motor Cortical and Corticospinal Excitability: Physiology, Function, and Plasticity
- The size of motor-evoked potentials: influencing parameters and quantification
- The cortical silent period
- Paired-pulse measures
- Evaluating the interaction between cortical inhibitory and excitatory circuits measured by TMS
- Pharmacology of TMS measures
- Transcranial stimulation measures explored by epidural spinal cord recordings
- TMS measures and voluntary motor function
- Changes in TMS Measures induced by repetitive TMS
- Neuroplasticity induced by transcranial direct current stimulation
- Use-dependent changes in TMS measures
- Section III The Motor-evoked Potential in Health and Disease
- The MEP in clinical neurodiagnosis
- TMS in the perioperative period
- TMS in movement disorders
- TMS: neurodevelopment and perinatal insults
- Using the TMS-induced Motor-evoked potential to evaluate the neurophysiology of psychiatric disorders
- Tms in Migraine
- Design and analysis of motor-evoked potential data in pediatric neurobehavioral disorder investigations
- Inter- and intra-individual variation in the response to TMS
- Section IV TMS in Perception and Cognition
- TMS and visual awareness
- Higher visual cognition: search, neglect, attention, and eye movements
- Studies of Crossmodal Functions with TMS
- Motor cognition: TMS studies of action generation
- Investigating language organization with TMS
- Higher cognitive functions: memory and reasoning
- Mathematics and TMS
- Section V TMS and Brain Mapping
- Combining brain imaging with brain stimulation: causality and connectivity
- TMS and positron emission tomography: methods and current advances
- Concurrent TMS and functional magnetic resonance imaging: methods and current advances
- TMS and electroencephalography: methods and current advances
- Section VI Therapeutic Applications of Tms
- Therapeutic potential of TMS-induced plasticity in the prefrontal cortex
- Methodological issues in clinical trial design for TMS
- TMS in the treatment of major depressive disorder
- TMS in bipolar disorder
- TMS clinical trials involving patients with schizophrenia
- TMS in the study and treatment of anxiety disorders
- Movement Disorders
- Brain stimulation in neurorehabilitation
- TMS and pain
- Table 46.3 Effects of repetitive TMS on chronic pain: targets other than the primary motor cortex
Abstract and Keywords
This article reviews the existing animal and human literature on the clinical potential of transcranial magnetic stimulation (TMS) in mania and bipolar depression, and discusses potential future directions for this work. Studies of TMS in depression and normal volunteers suggested lateral specificity of TMS-induced mood effects. Clinical trials to compare left versus right prefrontal TMS in mania have been developed. Studies to understand the effect of TMS in bipolar depression have been undertaken. The results show efficacy similar to that for unipolar depression. But this does not provide support for the concept of TMS as an anti-bipolar, or mood-stabilizing, treatment. The utility of TMS as prophylaxis for subsequent manic or depressive episodes has not been reported in bipolar disorder. More work is needed to clarify the risk of mood switch, and the potential of TMS as prophylaxis against future manic or depressive episodes.
Nimrod Grisaru, Beersheva Mental Health Center.
Bella Chudakov, Beersheva Mental Health Center.
Alex Kaptsan, Beersheva Mental Health Center.
Alona Shaldubina, Beersheva Mental Health Center.
Julia Applebaum, Beersheva Mental Health Center.
Robert Belmaker, Beersheva Mental Health Center.
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