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date: 03 August 2020

Abstract and Keywords

This article provides a conceptual framework, which contributes to the understanding of the mechanisms involved in brain stimulation. The relationship between the induced topographic electric field and specific sites and regions of nerve activation in the brain are still not precisely known. Nevertheless, there is much more specific information available concerning peripheral nerve and nerve root stimulation. In vitro studies provide insight into the different properties of monophasic versus polyphasic pulses. Studies of brain stimulation agree with the in vitro conclusion that the polyphasic pulse is more powerful than the monophasic pulse. The shape of the induced pulse may be a relevant clinical response factor in repetitive TMS.

Keywords: brain stimulation, electric field, nerve activation, in vitro studies, monophasic pulse, polyphasic pulse, repetitive TMS

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