The Oxford Handbook of Positive Psychology and Disability is the first comprehensive text providing a foundation for research and practice focusing on positive attributes of disability. The handbook’s introductory chapters introduce a paradigmatic change in how disability itself is understood, leading to the opportunity to focus research and practice regarding positive psychology’s emphasis on optimal human functioning to understand and support people with disabilities. The text provides chapters synthesizing research in traditional areas of positive psychology, including quality of life, satisfaction and well-being, hope, optimism, resilience, coping, and self-determination. Next, chapters addressing systemic applications in positive psychology to disability provide information on issues pertaining to career development and career thoughts, positive behavior supports, supported employment, education, family systems, and during aging. In addition, the text provides chapters addressing the knowledge base pertaining to the positive psychology of specific types of disability, including cognitive and developmental disabilities, physical disabilities, emotional and behavioral disabilities, and autism spectrum disorders. The text provides a foundation for infusing positive psychology into disability research and practice, and disability issues into positive psychology.