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date: 21 November 2019

Abstract and Keywords

This chapter examines the role of psychosocial factors and stress-related neuroendocrine hormones in cancer progression. The neuroendocrine stress response appears to play a key role in modulating physiological pathways relevant to cancer progression. These include tumor angiogenesis, invasion, anoikis, inflammation, the cellular immune response, and various cell-signaling pathways. These stress-response pathways also potentially interact with cancer treatments. Bidirectional influences of tumor-derived cytokines and other molecules on the hypothalamic pituitary adrenal (HPA) axis and CNS processes are also discussed along with implications for disease progression and survival. These mechanisms point to emerging possibilities for psychosocial, pharmacological, and integrative medicine interventions that have the potential to alter stress-response signaling pathways in cancer.

Keywords: cancer, stress, depression, immunity, inflammation, angiogenesis, invasion, psychoneuroimmunology

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