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date: 14 November 2019

Abstract and Keywords

Fatigue and sleep disturbance are rampant in today's society and bear significant costs in terms of health-care dollars, productivity, social relationships, and individual quality of life. Fatigue and sleep disturbance often co-occur in relatively healthy populations as well as in several clinical populations. This chapter discusses the psychoneuroimmunological underpinnings of fatigue and sleep disturbance, focusing specifically on the role of pro-inflammatory cytokines as contributors to both fatigue and sleep problems. The chapter provides a basic review of fatigue and sleep, as well as neuro-immune processes underlying these behaviors. Perpetuating factors, treatment approaches, and future research directions are also discussed.

Keywords: fatigue, sleep, sleepiness, sickness behavior, inflammation, HPA

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