- Oxford Library Of Psychology
- The Oxford Handbook of Obsessive Compulsive and Spectrum Disorders
- Short Contents
- Oxford Library of Psychology
- About the Editor
- Phenomenology and Epidemiology of Obsessive Compulsive Disorder
- Phenomenology and Epidemiology of Body Dysmorphic Disorder
- Phenomenology and Characteristics of Compulsive Hoarding
- Phenomenology and Epidemiology of Tic Disorders and Trichotillomania
- Genetic Understanding of OCD and Spectrum Disorders
- Neuroanatomy of Obsessive Compulsive and Related Disorders
- Information Processing in Obsessive Compulsive Disorder and Related Problems
- The Role of Family and Social Relationships in OCD and Spectrum Conditions
- Personality Features of OCD and Spectrum Conditions
- Psychological Models of Obsessive Compulsive and Spectrum Disorders: <i>From Psychoanalytic to Behavioral Conceptualizations</i>
- Cognitive Approaches to Understanding Obsessive Compulsive and Related Disorders
- Assessing OCD Symptoms and Severity
- Assessing Comorbidity, Insight, Family and Functioning in OCD
- Pharmacological Treatments for Obsessive Compulsive Disorder
- Other Biological Approaches to OCD
- Exposure-Based Treatment for Obsessive Compulsive Disorder
- Cognitive Treatment for OCD
- Combining Pharmacotherapy and Psychological Treatments for OCD
- Additive and Alternative Approaches to Treating Obsessive Compulsive Disorder
- Treatment of Body Dysmorphic Disorder
- Treatment of Compulsive Hoarding
- Treatment of Tic Disorders and Trichotillomania
- OCD and Spectrum Conditions in Older Adults
- Obsessive Compulsive Spectrum Disorders in Children and Adolescents
- Cultural Issues in Understanding and Treating Obsessive Compulsive and Spectrum Disorders
- Future Research on Obsessive Compulsive and Spectrum Conditions
Abstract and Keywords
This chapter reviews the evidence for the genetic etiology of OCD and spectrum conditions. A genetic basis is supported by the familial aggregation of OCD; evidence for involvement of genes of major effect in segregation analyses; and higher concordance for OCD in identical than non-identical twins. Recent studies also support linkage of OCD to specific chromosomal regions and association of OCD with specific genetic polymorphisms. However, specific genes causing OCD have not yet been firmly established. The search for genes is complicated by the clinical and etiologic heterogeneity of OCD, as well as the possibility of gene–gene and gene–environmental interactions. Despite this complexity, developments in molecular and statistical genetics, and further refinement of the phenotype hold promise for further deepening our genetic understanding of OCD and spectrum disorders in the coming decade.
Jack Samuels, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD
Marco A. Grados, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD.
Elizabeth Planalp, Department of Psychology, Loyola College, Baltimore, MD.
O. Joseph Bienvenu, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD.
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