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date: 03 July 2022

Abstract and Keywords

Chronic low grade inflammation is a core pathophysiological process that may be involved in many age-related diseases. Elevations in circulating markers of inflammation have been associated with frailty and disability, osteoporosis, certain cancers, cardiovascular disorders, type II diabetes, rheumatoid arthritis, and Alzheimer’s disease. Importantly, stress and negative emotions appear to promote the production of inflammatory mediators, providing a physiological mechanism by which negative psychological states may impact health. This chapter reviews the basic physiological processes of inflammation, the relationships among stress, negative emotions, social relationships, and inflammation, and the behavioral and physiological pathways linking stress, emotions, and inflammation.

Keywords: inflammation, Interleukin-6, C-Reactive protein, glucocorticoid resistance, stress, depression, caregiving, social support, social conflict, marriage, health behaviors, chronic disease, psychoneuroimmunology

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