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date: 03 August 2020

Abstract and Keywords

GABAergic transmission mediated by anion-permeable GABAA receptor-channels is one of the most fundamental mechanisms of neuronal communication in the brain at the cellular and systems level. During development, there is a qualitative change in GABA A signaling from depolarizing and often even excitatory responses, displayed by immature neurons, to the “conventional” inhibitory actions observed in the adult. An increasing amount of evidence points to bidirectional interactions, where GABAergic signaling shapes the functional as well as structural properties of neurons and neuronal networks. This chapter reviews the molecular basis of the ontogeny of GABA actions with an emphasis on GABA A receptors and ion-transport mechanisms. With a focus on the hippocampus, the chapter shows how this kind of information can be used in understanding the development of endogenous and evoked network events.

Keywords: GABA, neuronal communication, bidirectional interactions, GABAA receptors, ion-transport mechanisms, hippocampus

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