Abstract and Keywords
This chapter reviews issues related to the inheritance of anxiety disorders and related traits. Studies in genetic epidemiology (twin and family studies) were used to establish first that traits were heritable, then to examine the range of genetic expression of relevant traits. Molecular studies (linkage and association studies) were used to identify chromosomal regions that might harbor risk genes, and to establish relationships of variation in specific candidate genes with specific traits, respectively. Rapid advances in methodology applicable to complex trait genetics (including psychiatric traits) have led to considerable progress in recent years, with the promise of much more to come with the advent of genomewide association methods.
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