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date: 30 May 2020

Abstract and Keywords

This chapter is designed to provide an integrated perspective on the issues and efficacy associated with the application of combined cognitive behavioral therapy (CBT) and pharmacotherapy for the anxiety disorders. Important practice characteristics, including the availability, cost, effort, and tolerability of each treatment, are discussed along with a review of efficacy findings. The ongoing hope that combination treatment (CBT plus antidepressants or benzodiazepines) will provide an especially efficacious or cost-effective treatment has not been realized. The chapter closes with consideration of some of the novel and promising combination treatment strategies (e.g., isolated use of D-cycloserine) that, instead of relying on direct treatment of affective disorders, target pharmacotherapy toward the promotion of more optimal learning in CBT.

Keywords: cognitive behavioral therapy, combination treatment, efficacy, nonresponse, pharmacotherapy, treatment tolerability

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