- Oxford Library of Psychology
- [UNTITLED]
- Contributors
- Overview and Introduction to Anxiety Disorders
- Epidemiology of Anxiety Disorders
- Phenomenology of Panic and Phobic Disorders
- Phenomenology of Generalized Anxiety Disorder
- Phenomenology of Obsessive-Compulsive Disorder
- Phenomenology of Posttraumatic Stress Disorder and Acute Stress Disorder
- Preclinical Approaches to Understanding Anxiety Disorders
- Heritability and Genetics of Anxiety Disorders
- Neuroanatomy and Neuroimaging of Anxiety Disorders
- Neuroendocrinology of Anxiety Disorders
- Developmental Approaches to Understanding Anxiety Disorders
- Information-Processing Approaches to Understanding Anxiety Disorders
- Understanding Anxiety Disorders from a “Triple Vulnerability” Framework
- Familial and Social Environments in the Etiology and Maintenance of Anxiety Disorders
- Personality Factors in the Anxiety Disorders
- Psychological Models of Phobic Disorders and Panic
- Psychological Models of Worry and Generalized Anxiety Disorder
- Psychological Approaches to Understanding Obsessive-Compulsive Disorder
- Psychological Models of Posttraumatic Stress Disorder and Acute Stress Disorder
- Classification and Boundaries Among Anxiety-Related Problems
- Assessment of Anxiety Disorders
- Pharmacotherapy for Panic Disorder and Agoraphobia
- Psychological Treatment of Panic Disorder and Agoraphobia
- Pharmacotherapy for Social Anxiety Disorder and Specific Phobia
- Psychological Treatment of Social Anxiety Disorder and Specific Phobia
- Pharmacotherapy for Generalized Anxiety Disorder
- Psychological Treatment of Generalized Anxiety Disorder
- Biological Treatment for Obsessive-Compulsive Disorder
- Psychological Treatment of Obsessive-Compulsive Disorder
- Pharmacotherapy for Posttraumatic Stress Disorder and Other Trauma-Related Disorders
- Psychological Treatment of Posttraumatic Stress Disorder and Acute Stress Disorder
- Combining Pharmacological and Cognitive Behavioral Therapy in the Treatment of Anxiety Disorders
- Integrated Psychological Treatment of Multiple Anxiety Disorders
- Complementary and Alternative Approaches to Treating Anxiety Disorders
- Exposure-Based Treatments for Anxiety Disorders: Theory and Process
- Mindfulness and Acceptance-Based Treatments for Anxiety Disorders
- Self-Help Treatments for Anxiety Disorders
- Prevention of Child and Youth Anxiety and Anxiety Disorders
- Managing Anxiety in Primary Care
- Hypochondriasis and Health Anxiety
- Body Dysmorphic Disorder
- Fear of Pain
- Anxiety Disorders and Substance Use Disorder Comorbidity
- Anxiety Disorders and Depression Comorbidity
- Anxiety Disorders and Personality Disorders Comorbidity
- Anxiety Disorders and Physical Comorbidity
- Anxiety and Sleep
- Anxiety Disorders and Hoarding in Older Adults
- Anxiety Disorders in Children and Adolescents
- Anxiety and Culture
- Future Directions in Anxiety Disorders Research
- Index
Abstract and Keywords
Posttraumatic stress disorder (PTSD) can cause serious chronic psychological impairments in a significant number of persons who have been exposed to an extreme traumatic event. Finding effective, well-tolerated pharmacological treatments for this disorder is an ongoing research effort. This chapter reviews recent thinking that PTSD results from dysfunctions in the neural systems mediating fear learning and memory. These systems are modulated by dopamine, GABA, norepinephrine, and serotonin. Drugs that have been investigated to alleviate PTSD symptoms affect these neuromodulators and include all classes of antidepressants, mood stabilizers, and antipsychotics. To date, the SSRI antidepressants, particularly paroxetine, have shown the best evidence for alleviating most PTSD symptoms in most people. Drugs that promote extinction of fear learning are currently being investigated.
Keywords: acute stress, anticonvulsants, antidepressants, antipsychotics, mood stabilizers, neurobiology, pharmacotherapy, posttraumatic stress disorder
Mary F. Dent, Emory Clinical Neurosciences Research Unit, Emory University.
J. Douglas Bremner, Departments of Psychiatry and Behavioral Sciences and Radiology, Emory University School of Medicine, Atlanta, GA, Atlanta VAMC, Decatur, GA
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- Oxford Library of Psychology
- [UNTITLED]
- Contributors
- Overview and Introduction to Anxiety Disorders
- Epidemiology of Anxiety Disorders
- Phenomenology of Panic and Phobic Disorders
- Phenomenology of Generalized Anxiety Disorder
- Phenomenology of Obsessive-Compulsive Disorder
- Phenomenology of Posttraumatic Stress Disorder and Acute Stress Disorder
- Preclinical Approaches to Understanding Anxiety Disorders
- Heritability and Genetics of Anxiety Disorders
- Neuroanatomy and Neuroimaging of Anxiety Disorders
- Neuroendocrinology of Anxiety Disorders
- Developmental Approaches to Understanding Anxiety Disorders
- Information-Processing Approaches to Understanding Anxiety Disorders
- Understanding Anxiety Disorders from a “Triple Vulnerability” Framework
- Familial and Social Environments in the Etiology and Maintenance of Anxiety Disorders
- Personality Factors in the Anxiety Disorders
- Psychological Models of Phobic Disorders and Panic
- Psychological Models of Worry and Generalized Anxiety Disorder
- Psychological Approaches to Understanding Obsessive-Compulsive Disorder
- Psychological Models of Posttraumatic Stress Disorder and Acute Stress Disorder
- Classification and Boundaries Among Anxiety-Related Problems
- Assessment of Anxiety Disorders
- Pharmacotherapy for Panic Disorder and Agoraphobia
- Psychological Treatment of Panic Disorder and Agoraphobia
- Pharmacotherapy for Social Anxiety Disorder and Specific Phobia
- Psychological Treatment of Social Anxiety Disorder and Specific Phobia
- Pharmacotherapy for Generalized Anxiety Disorder
- Psychological Treatment of Generalized Anxiety Disorder
- Biological Treatment for Obsessive-Compulsive Disorder
- Psychological Treatment of Obsessive-Compulsive Disorder
- Pharmacotherapy for Posttraumatic Stress Disorder and Other Trauma-Related Disorders
- Psychological Treatment of Posttraumatic Stress Disorder and Acute Stress Disorder
- Combining Pharmacological and Cognitive Behavioral Therapy in the Treatment of Anxiety Disorders
- Integrated Psychological Treatment of Multiple Anxiety Disorders
- Complementary and Alternative Approaches to Treating Anxiety Disorders
- Exposure-Based Treatments for Anxiety Disorders: Theory and Process
- Mindfulness and Acceptance-Based Treatments for Anxiety Disorders
- Self-Help Treatments for Anxiety Disorders
- Prevention of Child and Youth Anxiety and Anxiety Disorders
- Managing Anxiety in Primary Care
- Hypochondriasis and Health Anxiety
- Body Dysmorphic Disorder
- Fear of Pain
- Anxiety Disorders and Substance Use Disorder Comorbidity
- Anxiety Disorders and Depression Comorbidity
- Anxiety Disorders and Personality Disorders Comorbidity
- Anxiety Disorders and Physical Comorbidity
- Anxiety and Sleep
- Anxiety Disorders and Hoarding in Older Adults
- Anxiety Disorders in Children and Adolescents
- Anxiety and Culture
- Future Directions in Anxiety Disorders Research
- Index
