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date: 26 February 2021

Abstract and Keywords

This article considers research methodologies relevant to the search for molecular mechanisms of cognitive functions. It proposes a new general framework for understanding contemporary science called the science of research (SR). It discusses two scientific puzzles concerning the neurobiology of cognitive functions and some recently noticed inefficiencies in institutionalized science across the board. It suggests that both of these puzzle can be addressed by the SR framework for discovering and testing hypotheses about science. It also discusses the so-called positive and negative alteration and describes Koch's postulates, John Stuart Mill's methods, and reductionism in actual scientific practice.

Keywords: research methodologies, molecular mechanisms, cognitive functions, science of research, neurobiology, scientific inefficiencies, Koch's postulates, John Stuart Mill's methods, reductionism

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