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A History of Pain ResearchFernando Cervero and John N. Wood The Measurement of Pain in the Laboratory RodentJeffrey S. Mogil Invertebrate Models of Nociception: Learning From Flies and WormsDaniel Hesselson, Denise S. Walker, Joshua Neil Massingham, William R. Schafer, G. Gregory Neely, and Yee Lian Chew Human Genetics of PainJames J. Cox, Ingo Kurth, and C. Geoffrey Woods Dorsal Root Ganglion Neuron Types and Their Functional SpecializationEdward C. Emery and Patrik Ernfors The Sympathetic Nervous System and PainJudith A. Strong, Jun-Ming Zhang, and Hans-Georg Schaible Heat Pain and Cold Pain Félix Viana and Thomas Voets Noxious MechanosensationPatrick Delmas, Sergiy Mikhailovych Korogod, and Bertrand Coste Sodium Channels and PainTheodore R. Cummins, Stephen G. Waxman, and John N. Wood Potassium Channels and PainJérôme Busserolles, Xavier Gasull, and Jacques Noël Voltage-Gated Calcium Channels: Molecular Targets for Treating Chronic PainGerald W. Zamponi, Maria A. Gandini, and Terry P. Snutch Chloride Channels in NociceptorsUhtaek Oh and Jooyoung Jung Neuroimmune Interactions and PainJiahe Li and Peter M. Grace The Neurobiology of Pain: Development and SexMaria Fitzgerald and Michael W. Salter Central Nervous System Pain PathwaysAndrew J. Todd and Fan Wang Dorsal Horn Pain MechanismsHanns Ulrich Zeilhofer and Robert Ganley Visceral PainDavid C. Bulmer and Carolina Roza fMRI and Human Pain PerceptionGiandomenico Iannetti and A. Vania Apkarian Neurobiological Basis of MigrainePhilip R. Holland, Jan Hoffmann, and Peter J. Goadsby Effect of Sleep Loss on PainChloe Alexandre, Alban Latremoliere, and Patrick H. Finan Sensory Signaling Pathways in Inflammatory and Neuropathic PainHanneke L. D. M. Willemen and Niels Eijkelkamp The Diversity of Neuropathic Pain Nanna Brix Finnerup and Nadine Attal The Transition from Acute to Chronic PainWei-Hsin Sun, Yu-Shiuan Su, and Chih-Cheng Chen Cancer and PainRie Bager Hansen and Sarah Falk Opioids and PainChristoph Stein and Claire Gaveriaux-Ruff Neurotrophins, Cytokines, and PainShafaq Sikandar and Claudia Sommer Chemo- and Optogenetic Strategies for the Elucidation of Pain PathwaysSascha R.A. Alles, Anne-Marie Malfait, and Richard J. Miller Autoantibodies and Neuropathic PainJohn M. Dawes and David L. Bennett The Proteomics and Metabolomics of Pain: Opportunities for Systems MedicineDavid Gomez-Varela and Manuela Schmidt