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date: 21 May 2019

Abstract and Keywords

This chapter provides a state-of-the-science summary of the neurobiology of agrammatism, an acquired impairment of grammar that may result from stroke or neurodegenerative disease (i.e., primary progressive aphasia). The chapter provides an overview of the language-deficit patterns that characterize agrammatism, such as impaired verb retrieval, verb inflection, verb-argument structure, and production and comprehension of complex sentences. The neurocognitive mechanisms of these deficit patterns are also reviewed, with particular emphasis on recent studies examining the real-time mechanisms of agrammatism and their neural correlates. The picture that emerges is that agrammatism results from impairments of grammatical processing, rather than grammatical knowledge. These deficits largely arise from damage to left hemisphere dorsal language pathways, in particular temporal-parietal and inferior frontal language regions and dorsal white matter tracts.

Keywords: agrammatism, neurodegenerative disease, neurocognitive, verb argument structure, sentence comprehension, sentence production

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