This chapter argues that Critical Security Studies (CSS), a diverse range of approaches that have questioned traditional ways of conceiving security, can provide a useful set of tools for understanding global health. CSS enables rich analyses of how health problems emerge as matters of security and allows one to discern the underlying conditions that make this possible, as well as the effects of framing diseases as threats. It also shows how health security can be conceived as a layered phenomenon, encompassing not just state and regional stability but also the everyday lives of individuals and groups. The chapter contextualizes and lays out the core tenets of CSS, then shows how some of the core concepts in the CSS literature can be applied to analysis of health issues. Finally, the chapter demonstrates how CSS can function as a privileged entry point into the political dimensions of the current global health regime.