Derya Sargin, Chen Yan, and Sheena Josselyn
Fear is an important emotion; remembering fearful events/places/stimuli is key for survival. However, dysregulation of fear may underlie the etiology of several psychiatric diseases. Inappropriate storage and/or recall of fearful events can lead to maladaptive fear behaviors and physiological responses that contribute to emotional disorders. Much research has provided insights into the neural processes mediating the formation of fear memories. In addition, some new research has begun to provide insights into how fear memories may be weakened. A more thorough understanding of the molecular, cellular, and circuit basis of the formation and storage of fear memories may one day provide insights into how we can rid ourselves of aberrant fear memories associated with psychopathological responses.