- Oxford Library of Psychology
- Oxford Library of Psychology
- About the Editors
- Introduction to The Oxford Handbook of Cognitive Neuroscience: Cognitive Neuroscience: Where Are We Now?
- Salience, State, and Expression: The Influence of Specific Aspects of Emotion on Attention and Perception
- Emotion: Generation or Construction?
- The Neuroscience of Emotion Regulation: Basic Mechanisms and Their Role in Development, Aging, and Psychopathology
- The Impact of Emotion on Cognition
- Genetics and Emotion
- Visceromotor Sensation and Control
- Development of Emotion and Social Reasoning in Adolescence
- Perception of Nonverbal Cues
- Face Recognition
- The Cognitive and Neural Basis of Impression Formation
- Theory of Mind: How Brains Think about Thoughts
- The Pleasures and Pains of Social Interactions: A Social Cognitive Neuroscience Perspective
- The Neural Underpinnings of the Experience of Empathy: Lessons for Psychopathy
- Mirror Neurons and the Perception–Action Link
- The Early Development of the Brain Bases for Social Cognition
- Conflict Monitoring and Cognitive Control
- Hierarchical Cognitive Control and the Functional Organization of the Frontal Cortex
- Decision Neuroscience
- Expectancies and Beliefs: Insights from Cognitive Neuroscience
- Cognitive Neuroscience of Numerical Cognition
- Psychopharmacology of Cognition
- Attention Deficit/Hyperactivity Disorder (ADHD)
- Post-Traumatic Stress Disorder (PTSD)
- Generalized Anxiety Disorder and Social Phobia Considered from a Cognitive Neuroscience Perspective
- The Neurobiology of Obsessive-Compulsive Disorder
- Epilogue to The Oxford Handbook of Cognitive Neuroscience Cognitive Neuroscience: Where Are We Going?
Abstract and Keywords
Obsessive-compulsive disorder (OCD) is a debilitating and prevalent neuropsychiatric disorder characterized by obsessions and/or compulsions. This chapter selectively reviews OCD from several perspectives. It begins by considering clinical features of the disorder and its relationship with putative OC spectrum conditions such as trichotillomania and Tourette’s syndrome. Existing first-line pharmacological and psychological interventions are outlined. The chapter then considers what is known of the neurobiology of OCD, focusing on relatively functionally segregated frontostriatal circuitry and underlying neurochemical mediators. It is proposed that OCD symptoms, and associated cognitive deficits, can be conceptualized in terms of aberrant function of orbitofrontocortical and dorsolateral prefrontocortical circuitry. This model is supported by translational studies relating to three specific cognitive functions: reversal learning, set-shifting, and response inhibition. Problems in these domains, along with associated neural abnormalities, have been found in patients with OCD and in their clinically unaffected first-degree relatives. Shortcomings in the literature are then discussed and future research directions provided, including the search for validated endophenotypes and novel treatment approaches for OCD and related disorders.
Samuel R. Chamberlain, Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Naomi A. Fineberg, National OCDs Treatment Service, Hertfordshire Partnership NHS Foundation Trust, Welwyn Garden City, UK, University of Hertfordshire, Hatfield, UK
Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.