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date: 26 September 2020

Abstract and Keywords

Memory is one of the cognitive functions that deteriorate most with age. The types of memory most affected by aging are working memory, the short-term memory maintenance and simultaneous manipulation of information, and episodic memory, our memory for personally experienced past events. Functional neuroimaging studies indicate important roles in age-related memory decline for the medial temporal lobe (MTL) and prefrontal cortex (PFC) regions, which have been linked to two major cognitive aging theories, the resource and binding deficit hypotheses, respectively. Interestingly, functional neuroimaging findings also indicate that aging is not exclusively associated with decline. Some older adults seem to deal with PFC and MTL decline by shifting to alternative brain resources that can compensate for their memory deficits. In the future, these findings may help to distinguish normal aging from early Alzheimer’s dementia and the development of memory remediation therapies.

Keywords: functional neuroimaging, aging, working memory, episodic memory, medial temporal lobe, prefrontal cortex

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