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date: 03 March 2021

Abstract and Keywords

Borderline personality disorder (BPD) is a severe form of psychopathology that is characterized by instability in emotions, behavior, relationships, and self-concept. Patients with BPD are challenging to treat and are at serious risk of suicide. Although the etiology of BPD is not well understood, genetic factors are implicated, as are adverse experiences in childhood. These factors may interact to create problems with neural circuits that are involved in regulation of affect, behavior, and cognition. In this chapter we describe the clinical aspects of the disorder and review its etiology. We also highlight findings from the empirical literature concerning the neurobiology and psychopathology associated with the disorder.

Keywords: borderline personality disorder, instability, emotional dysregulation, etiology, risk, neurobiology

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