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date: 28 September 2020

Abstract and Keywords

Comorbidity between externalizing and internalizing disorders, which occurs at much higher rates than expected by chance, has long been a focus of empirical research. In this chapter, we provide an overview of issues related to heterotypic comorbidity, including studies of sex differences in externalizing and internalizing liabilities, evidence demonstrating moderating effects of comorbid anxiety on aspects of externalizing disorders, and perspectives on comorbidity that have emerged from research on family and peer socialization risk factors, based on both attachment and social learning models. Implications of comorbid externalizing and internalizing conditions for psychosocial and pharmacological treatments are also examined, along with potential directions for future research.

Keywords: internalizing, externalizing, comorbidity, DSM-5, sex differences, socialization, Research Domain Criteria (RDoC)

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