Abstract and Keywords
This chapter provides an overview of key concepts in designing and evaluating clinical trials. Our focus is on randomized controlled trials for PTSD. In the first section we discuss design elements and how they influence the conclusions that can be drawn from a study. Examples from the trauma literature are provided when available to illustrate concepts. In the second section we explore newer developments in PTSD treatment trials. Specifically, we discuss treatment and design considerations related to common comorbid conditions of PTSD, cultural issues in PTSD, and optimizing the delivery of treatments. Our goal is to improve both clinicians and researchers ability to critically review PTSD clinical trials.
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