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date: 26 January 2021

Abstract and Keywords

Inflammation is acknowledged as a risk factor for the onset and development of cardiovascular disease (CVD). This has led some to hypothesize that inflammation is a possible mechanism that may mediate, in part, the relation of CVD to factors associated with increased CVD risk—hostility, anger, and depression. This chapter reviews the empirical evidence of the associations between biomarkers of inflammation and hostility, anger and depression, alone and in combination. Before doing so, I present a brief description and review of the role of inflammation in disease development and the methods used to measure inflammation at point-of-care and in research laboratories. Lastly, I review preliminary data suggesting that gender and adiposity may potentially mediate and moderate the relationship between depression and inflammation.

Keywords: Inflammation, cytokines, hostility, anger, depression, depressive symptoms, cardiovascular disease, gender

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