- Copyright Page
- Dedication
- Oxford Handbooks in Neuroscience
- Preface
- Acknowledgments
- About the Editor
- Contributors
- A History of Pain Research
- The Measurement of Pain in the Laboratory Rodent
- Invertebrate Models of Nociception: Learning From Flies and Worms
- Human Genetics of Pain
- Dorsal Root Ganglion Neuron Types and Their Functional Specialization
- The Sympathetic Nervous System and Pain
- Heat Pain and Cold Pain
- Noxious Mechanosensation
- Sodium Channels and Pain
- Potassium Channels and Pain
- Voltage-Gated Calcium Channels: Molecular Targets for Treating Chronic Pain
- Chloride Channels in Nociceptors
- Neuroimmune Interactions and Pain
- The Neurobiology of Pain: Development and Sex
- Central Nervous System Pain Pathways
- Dorsal Horn Pain Mechanisms
- Visceral Pain
- fMRI and Human Pain Perception
- Neurobiological Basis of Migraine
- Effect of Sleep Loss on Pain
- Sensory Signaling Pathways in Inflammatory and Neuropathic Pain
- The Diversity of Neuropathic Pain
- The Transition from Acute to Chronic Pain
- Cancer and Pain
- Opioids and Pain
- Neurotrophins, Cytokines, and Pain
- Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways
- Autoantibodies and Neuropathic Pain
- The Proteomics and Metabolomics of Pain: Opportunities for Systems Medicine
- Index
Abstract and Keywords
Pain is not a simple phenomenon and, beyond its conscious perception, involves circuitry that allows the brain to provide an affective context for nociception, which can influence mood and memory. In the past decade, neurobiological techniques have been developed that allow investigators to elucidate the importance of particular groups of neurons in different aspects of the pain response, something that may have important translational implications for the development of novel therapies. Chemo- and optogenetics represent two of the most important technical advances of recent times for gaining understanding of physiological circuitry underlying complex behaviors. The use of these techniques for teasing out the role of neurons and glia in nociceptive pathways is a rapidly growing area of research. The major findings of studies focused on understanding circuitry involved in different aspects of nociception and pain are highlighted in this article. In addition, attention is drawn to the possibility of modification of chemo- and optogenetic techniques for use as potential therapies for treatment of chronic pain disorders in human patients.
Keywords: chemogenetics, optogenetics, nociception, pain, DREADD
Sascha R. A. Alles, University College London, UK
Anne-Marie Malfait, Rush University, USA
Richard J. Miller, Northwestern University, USA
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- Copyright Page
- Dedication
- Oxford Handbooks in Neuroscience
- Preface
- Acknowledgments
- About the Editor
- Contributors
- A History of Pain Research
- The Measurement of Pain in the Laboratory Rodent
- Invertebrate Models of Nociception: Learning From Flies and Worms
- Human Genetics of Pain
- Dorsal Root Ganglion Neuron Types and Their Functional Specialization
- The Sympathetic Nervous System and Pain
- Heat Pain and Cold Pain
- Noxious Mechanosensation
- Sodium Channels and Pain
- Potassium Channels and Pain
- Voltage-Gated Calcium Channels: Molecular Targets for Treating Chronic Pain
- Chloride Channels in Nociceptors
- Neuroimmune Interactions and Pain
- The Neurobiology of Pain: Development and Sex
- Central Nervous System Pain Pathways
- Dorsal Horn Pain Mechanisms
- Visceral Pain
- fMRI and Human Pain Perception
- Neurobiological Basis of Migraine
- Effect of Sleep Loss on Pain
- Sensory Signaling Pathways in Inflammatory and Neuropathic Pain
- The Diversity of Neuropathic Pain
- The Transition from Acute to Chronic Pain
- Cancer and Pain
- Opioids and Pain
- Neurotrophins, Cytokines, and Pain
- Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways
- Autoantibodies and Neuropathic Pain
- The Proteomics and Metabolomics of Pain: Opportunities for Systems Medicine
- Index
