- Copyright Page
- Dedication
- Oxford Handbooks in Neuroscience
- Preface
- Acknowledgments
- About the Editor
- Contributors
- A History of Pain Research
- The Measurement of Pain in the Laboratory Rodent
- Invertebrate Models of Nociception: Learning From Flies and Worms
- Human Genetics of Pain
- Dorsal Root Ganglion Neuron Types and Their Functional Specialization
- The Sympathetic Nervous System and Pain
- Heat Pain and Cold Pain
- Noxious Mechanosensation
- Sodium Channels and Pain
- Potassium Channels and Pain
- Voltage-Gated Calcium Channels: Molecular Targets for Treating Chronic Pain
- Chloride Channels in Nociceptors
- Neuroimmune Interactions and Pain
- The Neurobiology of Pain: Development and Sex
- Central Nervous System Pain Pathways
- Dorsal Horn Pain Mechanisms
- Visceral Pain
- fMRI and Human Pain Perception
- Neurobiological Basis of Migraine
- Effect of Sleep Loss on Pain
- Sensory Signaling Pathways in Inflammatory and Neuropathic Pain
- The Diversity of Neuropathic Pain
- The Transition from Acute to Chronic Pain
- Cancer and Pain
- Opioids and Pain
- Neurotrophins, Cytokines, and Pain
- Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways
- Autoantibodies and Neuropathic Pain
- The Proteomics and Metabolomics of Pain: Opportunities for Systems Medicine
- Index
Abstract and Keywords
Pain is a common and feared complication for many cancer patients. Cancer pain covers numerous pain syndromes; since the treatment is complex, it is essential to assess each individual patient with cancer pain thoroughly. Cancer pain includes not only elements of inflammatory and neuropathic pain, but also, importantly, cancer-specific elements. Starting with the clinical aspects of cancer pain and the current knowledge from in vivo models, this article provides an overview of the neurobiology known to drive cancer-induced bone pain as it evolves through the complex interplay between primary afferents, tumor cells, and bone cells. There continue to be many uncertainties and unknown mechanisms involved in cancer pain, and an effort to discover novel therapeutic targets should be emphasized as cancer pain poses an increasing clinical and socioeconomic burden.
Keywords: cancer pain, cancer-induced bone pain, in vivo models, clinical aspects, neurobiology
Rie Bager Hansen, University of Copenhagen, Denmark
Sarah Falk, University of Copenhagen, Denmark
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- Copyright Page
- Dedication
- Oxford Handbooks in Neuroscience
- Preface
- Acknowledgments
- About the Editor
- Contributors
- A History of Pain Research
- The Measurement of Pain in the Laboratory Rodent
- Invertebrate Models of Nociception: Learning From Flies and Worms
- Human Genetics of Pain
- Dorsal Root Ganglion Neuron Types and Their Functional Specialization
- The Sympathetic Nervous System and Pain
- Heat Pain and Cold Pain
- Noxious Mechanosensation
- Sodium Channels and Pain
- Potassium Channels and Pain
- Voltage-Gated Calcium Channels: Molecular Targets for Treating Chronic Pain
- Chloride Channels in Nociceptors
- Neuroimmune Interactions and Pain
- The Neurobiology of Pain: Development and Sex
- Central Nervous System Pain Pathways
- Dorsal Horn Pain Mechanisms
- Visceral Pain
- fMRI and Human Pain Perception
- Neurobiological Basis of Migraine
- Effect of Sleep Loss on Pain
- Sensory Signaling Pathways in Inflammatory and Neuropathic Pain
- The Diversity of Neuropathic Pain
- The Transition from Acute to Chronic Pain
- Cancer and Pain
- Opioids and Pain
- Neurotrophins, Cytokines, and Pain
- Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways
- Autoantibodies and Neuropathic Pain
- The Proteomics and Metabolomics of Pain: Opportunities for Systems Medicine
- Index
