- The Oxford Handbook of the Auditory Brainstem
- Oxford Handbooks in Neuroscience
- About the Editor
- Contributors
- Introduction and Overview
- Wiring the Cochlea for Sound Perception
- The Diversified Form and Function of Cochlear Afferents
- Efferent Innervation to the Cochlea
- The Cochlear Nuclei: Synaptic Plasticity in Circuits and Synapses in the Ventral Cochlear Nuclei
- In Vitro Studies of Neuromodulation and Plasticity in the Dorsal Cochlear Nucleus
- Molecular and Structural Changes in the Cochlear Nucleus in Response to Hearing Loss
- Age-Related and Noise-Induced Hearing Loss: Central Consequences in the Ventral Cochlear Nucleus
- The Cochlear Nucleus as a Generator of Tinnitus-Related Signals
- Multimodal Inputs to the Cochlear Nucleus and their Role in the Generation of Tinnitus
- Perinatal Development of the Medial Nucleus of the Trapezoid Body
- Extraction of Auditory Information by Modulation of Neuronal Ion Channels
- The Medial Superior Olivary Nucleus: Meeting the Need for Speed
- Lateral Superior Olive: Organization, Development, and Plasticity
- The Superior Paraolivary Nucleus
- Perineuronal Nets in the Superior Olivary Complex: Development, Function, and Plasticity
- The Nuclei of the Lateral Lemniscus
- Axon Trajectories in the Auditory Brainstem
- Neuron Types, Intrinsic Circuits, and Plasticity in the Inferior Colliculus
- Changes in the Inferior Colliculus Associated with Hearing Loss: Noise-Induced Hearing Loss, Age-Related Hearing Loss, Tinnitus and Hyperacusis
- Unifying the Midbrain: The Commissure of the Inferior Colliculus
- Neuromodulatory Feedback to the Inferior Colliculus
- Descending Auditory Pathways and Plasticity
- Aging Processes in the Subcortical Auditory System
- Glial Cells in the Auditory Brainstem
- Deviance Detection and Encoding Acoustic Regularity in the Auditory Midbrain
- Brainstem Encoding of Speech and Music Sounds in Humans
- The Auditory Brainstem Implant: Restoration of Speech Understanding from Electric Stimulation of the Human Cochlear Nucleus
- Index
Abstract and Keywords
As arguably the third most common malady of industrialized populations, age-related hearing loss is associated with social isolation and depression in a subset of the population that will approach 25% by 2050. Development of behavioral or pharmacotherapeutic approaches to prevent or delay the onset of age-related hearing loss and mitigate the impact of hearing loss of speech understanding requires a better understanding of age-related changes that occur in the central auditory processor. This chapter critically reviews and discusses changes that occur in the auditory brainstem and thalamus with increased age. It briefly discusses age-related cellular changes that occur de novo within the central auditory system versus deafferentation plasticity and animal models of aging. Subsections discuss the cochlear nucleus, superior olivary complex, inferior colliculus, and the medial geniculate body with an emphasis on age-related changes in neurotransmission and how these changes could underpin the observed loss of precise temporal processing with increased age.
Keywords: age-related hearing loss, presbycusis, brainstem aging, central auditory system, dorsal cochlear nucleus, superior olivary complex, inferior colliculus, medial geniculate body
Donald M. Caspary, Department of Pharmacology, Southern Illinois University School of Medicine; Department of Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine
Daniel A. Llano, Neuroscience Program, University of Illinois at Urbana-Champaign; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
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- The Oxford Handbook of the Auditory Brainstem
- Oxford Handbooks in Neuroscience
- About the Editor
- Contributors
- Introduction and Overview
- Wiring the Cochlea for Sound Perception
- The Diversified Form and Function of Cochlear Afferents
- Efferent Innervation to the Cochlea
- The Cochlear Nuclei: Synaptic Plasticity in Circuits and Synapses in the Ventral Cochlear Nuclei
- In Vitro Studies of Neuromodulation and Plasticity in the Dorsal Cochlear Nucleus
- Molecular and Structural Changes in the Cochlear Nucleus in Response to Hearing Loss
- Age-Related and Noise-Induced Hearing Loss: Central Consequences in the Ventral Cochlear Nucleus
- The Cochlear Nucleus as a Generator of Tinnitus-Related Signals
- Multimodal Inputs to the Cochlear Nucleus and their Role in the Generation of Tinnitus
- Perinatal Development of the Medial Nucleus of the Trapezoid Body
- Extraction of Auditory Information by Modulation of Neuronal Ion Channels
- The Medial Superior Olivary Nucleus: Meeting the Need for Speed
- Lateral Superior Olive: Organization, Development, and Plasticity
- The Superior Paraolivary Nucleus
- Perineuronal Nets in the Superior Olivary Complex: Development, Function, and Plasticity
- The Nuclei of the Lateral Lemniscus
- Axon Trajectories in the Auditory Brainstem
- Neuron Types, Intrinsic Circuits, and Plasticity in the Inferior Colliculus
- Changes in the Inferior Colliculus Associated with Hearing Loss: Noise-Induced Hearing Loss, Age-Related Hearing Loss, Tinnitus and Hyperacusis
- Unifying the Midbrain: The Commissure of the Inferior Colliculus
- Neuromodulatory Feedback to the Inferior Colliculus
- Descending Auditory Pathways and Plasticity
- Aging Processes in the Subcortical Auditory System
- Glial Cells in the Auditory Brainstem
- Deviance Detection and Encoding Acoustic Regularity in the Auditory Midbrain
- Brainstem Encoding of Speech and Music Sounds in Humans
- The Auditory Brainstem Implant: Restoration of Speech Understanding from Electric Stimulation of the Human Cochlear Nucleus
- Index
