Migraine is the most common disabling primary headache globally. Attacks often present with unilateral throbbing headache and an array of associated symptoms, including, nausea, multisensory hypersensitivity, and marked fatigue. The chapter focuses on the underlying neuroanatomical basis for migraine-related headache and associated symptomatology and discusses key clinical and preclinical findings that indicate that migraine likely results from dysfunctional homeostatic mechanisms.
This article by Philip R. Holland, Jan Hoffmann, and Peter J. Goadsby is a selection from The Oxford Handbook of the Neurobiology of Pain, edited by John N. Wood.
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