- Copyright Page
- Neurolinguistics: A Brief Historical Perspective
- Neurolinguistic Studies of Patients with Acquired Aphasias
- Electrophysiological Methods in the Study of Language Processing
- Studying Language with Functional Magnetic Resonance Imaging (fMRI)
- Transcranial Magnetic Stimulation to Study the Neural Network Account of Language
- Magnetoencephalography and the Cortical Dynamics of Language Processing
- Shedding Light on Language Function and Its Development with Optical Brain Imaging
- What Has Direct Cortical and Subcortical Electrostimulation Taught Us about Neurolinguistics?
- Diffusion Imaging Methods in Language Sciences
- Neuroplasticity: Language and Emotional Development in Children with Perinatal Stroke
- The Neurolinguistics of Bilingualism: Plasticity and Control
- Language and Aging
- Language Plasticity in Epilepsy
- Language Development in Deaf Children: Sign Language and Cochlear Implants
- Neuromotor Organization of Speech Production
- The Neural Organization of Signed Language: Aphasia and Neuroscience Evidence
- Understanding How We Produce Written Words: Lessons from the Brain
- Motor Speech Disorders
- Investigating the Spatial and Temporal Components of Speech Production
- The Dorsal Stream Auditory-Motor Interface for Speech
- Neural Representations of Concept Knowledge
- Finding Concepts in Brain Patterns: From Feature Lists to Similarity Spaces
- The How and What of Object Knowledge in the Human Brain
- Neural Basis of Monolingual and Bilingual Reading
- Dyslexia and Its Neurobiological Basis
- Speech Perception: A Perspective from Lateralization, Motorization, and Oscillation
- Sentence Processing: Toward a Neurobiological Approach
- Comprehension of Metaphors and Idioms: An Updated Meta-analysis of Functional Magnetic Resonance Imaging Studies
- Language Comprehension and Emotion: Where Are the Interfaces, and Who Cares?
- Grammatical Categories
- Neurocognitive Mechanisms of Agrammatism
- Verbal Working Memory
- Subcortical Contributions to Language
- Lateralization of Language
- Neural Mechanisms of Music and Language
Abstract and Keywords
This chapter provides a state-of-the-science summary of the neurobiology of agrammatism, an acquired impairment of grammar that may result from stroke or neurodegenerative disease (i.e., primary progressive aphasia). The chapter provides an overview of the language-deficit patterns that characterize agrammatism, such as impaired verb retrieval, verb inflection, verb-argument structure, and production and comprehension of complex sentences. The neurocognitive mechanisms of these deficit patterns are also reviewed, with particular emphasis on recent studies examining the real-time mechanisms of agrammatism and their neural correlates. The picture that emerges is that agrammatism results from impairments of grammatical processing, rather than grammatical knowledge. These deficits largely arise from damage to left hemisphere dorsal language pathways, in particular temporal-parietal and inferior frontal language regions and dorsal white matter tracts.
Cynthia K. Thompson is a Ralph and Jean Sundin Distinguished Professor of Communication Science, Professor of Neurology, and Director of the Center for the Neurobiology of Language Recovery (CNLR) at Northwestern University. Her work, supported by the National Institutes of Health throughout her academic career, examines normal and disordered sentence processing (and recovery in aphasia), using online (i.e., eye-tracking), multimodal neuroimaging, and other methods. She has published her work in more than 150 papers in referred journals, numerous book chapters, and two books.
Jennifer E. Mack is an Assistant Professor in the Department of Communication Disorders at the University of Massachusetts–Amherst. Her research focuses on the neural and cognitive basis of sentence processing impairments and recovery in aphasia, using methods such as eye-tracking and magnetic resonance imaging (MRI).
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