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Chemosensory Transduction in Arthropods  

Monika Stengl

Reception of chemicals via olfaction and gustation are prerequisites to find, distinguish, and recognize food and mates and to avoid dangers. Several receptor gene superfamilies are ... More

GABAA Receptor Physiology and Pharmacology  

Martin Wallner, Anne Kerstin Lindemeyer, and Richard W. Olsen

Online publication date:
Mar 2018
GABAA receptors (GABAARs) are the main inhibitory neurotransmitter receptors and mediate rapid synaptic as well as slow extrasynaptic inhibitory neurotransmission. Structurally, GABAARs ... More

Genetic Analysis of Behavior in Drosophila  

Björn Brembs

The main function of brains is to generate adaptive behavior. Far from being the stereotypical, robot-like insect, the fruit fly Drosophila exhibits astounding flexibility and chooses ... More

Mechanisms of Axonal Degeneration and Regeneration: Lessons Learned From Invertebrates  

Jiaxing Li and Catherine A. Collins

In the face of acute or chronic axonal damage, neurons and their axons undergo a number of molecular, cellular, and morphological changes. These changes facilitate two types of responses, ... More

Neurotransmitters and Neuropeptides of Invertebrates  

Lynne A. Fieber

This chapter introduces working definitions of neuropeptides and neurotransmitters from the perspective of invertebrate physiological processes. Neuropeptides and neurotransmitters are ... More

Nicotinic Acetylcholine Receptors  

Roger L. Papke

Online publication date:
Mar 2018
Acetylcholine, exquisitely evolved as a neurotransmitter, is made and released by the neurons that take the integrated output of the central nervous system throughout the body. At both ... More

P2X Receptors  

Annette Nicke, Thomas Grutter, and Terrance M. Egan

Online publication date:
Mar 2018
P2X receptors are ATP-gated ion channels that are ubiquitously expressed in eukaryotic tissues. They are involved in diverse physiological processes, from modulation of synaptic ... More

Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease  

Truus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. Proud

Online publication date:
Mar 2018
Vanishing white matter (VWM) disease is a recessive disorder characterized by gradual loss of white matter and of myelin. Its clinical severity is high variable. VWM is caused by mutations ... More

Specialized Sodium Channels in Pain Transmission  

Yucheng Xiao, Zifan Pei, and Theodore R. Cummins

Online publication date:
Mar 2018
Voltage-gated sodium channels (VGSCs) in peripheral sensory neurons play a critical role in transmitting information regarding noxious stimuli from the periphery to the central nervous ... More